Multiple stages in radiation carcinogenesis of rat skin.
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چکیده
منابع مشابه
Multiple stages in radiation carcinogenesis of rat skin.
Epithelial cell cancers are induced in rat skin by ionizing radiation in a manner that is consistent with the dual action (i.e., two alterations) hypothesis of radiation effects on DNA. This hypothesis states simply that two initial alterations, presumably in the DNA, are necessary to start a normal cell on the pathway to cancer. The initial radiation-induced alteration in the DNA is repairable...
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The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to the following radiations: 1. an electron beam (LET = 0.34 kev/mu), 2....
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1989
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.898167